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- $Unique_ID{BRK04293}
- $Pretitle{}
- $Title{Tropical Sprue}
- $Subject{Tropical Sprue Hill Diarrhea Tropical Diarrhea }
- $Volume{}
- $Log{}
-
- Copyright (C) 1986, 1989 National Organization for Rare Disorders, Inc.
-
- 89:
- Tropical Sprue
-
- ** IMPORTANT **
- It is possible that the main title of the article (Tropical Sprue) is not
- the name you expected. Please check the SYNONYM listing to find alternate
- names and disorder subdivisions covered by the article.
-
- Synonyms
-
- Hill Diarrhea
- Tropical Diarrhea
-
- General Discussion
-
- ** REMINDER **
- The information contained in the Rare Disease Database is provided for
- educational purposes only. It should not be used for diagnostic or treatment
- purposes. If you wish to obtain more information about this disorder, please
- contact your personal physician and/or the agencies listed in the "Resources"
- section of this report.
-
- Malabsorption, multiple nutritional deficiencies, and abnormalities in
- the small bowel mucosa are the chief characteristics in Tropical Sprue, a
- disorder of unknown cause. The disease is acquired and appears to be related
- to environmental and nutritional conditions. It is most prevalent in the
- Caribbean, south India, and southeast Asia.
-
- Symptoms
-
- Symptoms of Tropical Sprue may include fatigue, diarrhea with stools that are
- copious, pale and malodorous, anorexia, loss of weight, asthenia (loss of
- strength and energy) and general weakness.
-
- The onset of the disorder may be acute. There may be fever and an
- inflammation of the mouth and tongue. The skin may be dry and there may be
- scaling apparent on the lips and at the angles of the mouth. Some patients
- may experience mental depression.
-
- Some patients experience spontaneous remission. Treatment of the
- disorder in its early stages may result in rapid and complete recovery. The
- restoration of normal intestinal structure and function may be slower if
- treatment is begun later in the course of the disease. Tropical Sprue may
- become chronic with frequent relapses.
-
- Malabsorption of fats and xylose, reduction in the absorption of iron,
- vitamin B12, and folate, and megaloblastic anemia are common findings.
-
- Causes
-
- Tropical Sprue is a disease of unknown cause. It is an acquired disorder
- which appears to be related to environmental and nutritional conditions. The
- disease may be related to an infectious organism (either viral or bacterial),
- dietary toxin, parasitic infestation, or a nutritional deficiency such as
- folic acid. Damage to intestinal mucosa which results in an impairment of
- the absorption of foods, minerals, and water may be produced by these agents.
-
- Affected Population
-
- Tropical Sprue occurs chiefly in the Caribbean area, south India, and
- southeast Asia. Both residents of the area and visitors can be affected.
-
- Therapies: Standard
-
- Treatment for Tropical Sprue includes the use of folic acid and tetracycline
- or oxytetracycline or ampicillin. The dosage depends on the severity of the
- disorder as well as how the patient responds to the therapy. Other
- replacement therapy is given as needed (e.g., iron, vitamin B12). Diarrhea
- may be controlled with Lomotil or Imodium.
-
- Therapies: Investigational
-
- This disease entry is based upon medical information available through
- September 1989. Since NORD's resources are limited, it is not possible to
- keep every entry in the Rare Disease Database completely current and
- accurate. Please check with the agencies listed in the Resources section for
- the most current information about this disorder.
-
- Resources
-
- For more information on Tropical Sprue, please contact:
-
- National Organization for Rare Disorders (NORD)
- P.O. Box 8923
- New Fairfield, CT 06812-1783
- (203) 746-6518
-
- National Digestive Diseases Information Clearinghouse
- Box NDIC
- Bethesda, MD 20892
- (301) 468-2162
-
- Centers for Disease Control (CDC)
- 1600 Clifton Road, NE
- Atlanta, GA 30333
- (404) 639-3534
-
- References
-
- CECIL TEXTBOOK OF MEDICINE, 18th ed.: James B. Wyngaarden, and Lloyd H.
- Smith, Jr., Eds.: W. B. Saunders Co., 1988. P. 743.
-
- THE MERCK MANUAL 15th ed: R. Berkow, et al: eds; Merck, Sharp & Dohme
- Research Laboratories, 1987. P. 794.
-
-